PULMONARY TUBERCULOSIS AND GUILLAIN-BARRÉ SYNDROME (GBS): A CHANCE ASSOCIATION OR A Causal?

Praveen Kumar Javvaji, Padmaja Nagatham, Ramachandra Rao Iytha Venkata, Harivarsha Puttam

Abstract


Introduction & Objectives:   Although there are many case reports on GBS in patients with Tuberculosis since the incidence of the disease is rare, the association between them could not be tested. We attempt to compare all such cases along with a new case of Multi-drug resistant Tuberculosis (MDR TB) with GBS syndrome presented to us.

Materials and methods:

All the previously published cases on GBS in association with Tuberculosis and the present case were studied for common associations and comorbidities. Association between the time of onset of symptoms of Tuberculosis and that of GBS, prognosis, and recovery were compared.

Conclusions:

There is a temporal association between GBS and Tuberculosis. The symptoms of Tuberculosis preceded GBS by an average of 13 weeks. The etiology of GBS is immune mediated with molecular mimicry between epitopes of pathogens and host tissues being likely explanation.

Keywords


Guillain-Barré syndrome, Pulmonary Tuberculosis, Multi-drug resistant Tuberculosis.

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