DRUG UTILIZATION STUDY IN INDOOR ADULT ORGANOPHOSPHORUS POISONING PATIENTS AT A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

Sudharam. T. Bhagwate, Girish K. Chavhan, Rupesh A. Warbhe, Ananya Chakravorty, Anil V. Dindokar

Abstract


Background: Organophosphorous poisoning is a common medical emergency. Due to few drug utilization studies on
OP poisoning this study was carried out to evaluate the consumption pattern of commonly used drugs, according to PDD,
DDD/100 bed days and PDD/DDD ratio in patients treated for organophosphorus poisoning.
Material and Methods: A prospective observational study was carried out in a tertiary care hospital over four months
period from May to August 2018. Data was analysed using SPSS Software version 16.
Result: Total 64 organophosphorus poisoning cases were recorded, out of which 37(57.81 %) were males whereas
females were 27(42.18%). The majority of cases were from 21-30 years age group followed by 31-40 years age group.
Most of the cases 53 (82.82%) were from rural areas. PDD/DDD ratio values for Atropine and Cefotaxime were >1
suggesting overdosing of antidotes and antimicrobials in our MICU and medicine wards.
Conclusion: OPP is an important health concern where issues of antibiotic misuse and overuse are practiced.ATC/DDD
system is a tool for presenting drug utilization research in order to improve quality of drug use and is recommended by
WHO as international standard for drug utilization studies. Therefore, resident doctors and interns should be given
appropriate knowledge of ATC/DDD system for rational use of drugs. Improved adherence to infection control
practices, optimum utilisation of laboratory tests and antimicrobial stewardship programmes are very essential to curb
resistance and improve health benefit in OPP.


Keywords


Organophosphorous poisoning , ATC, WHO DDD, PDD/DDD ratio

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