ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CARCINOMA

Dr Monika Aggarwal, Dr V S Srinivas, Dr V S Nijhawan, Dr Vibha Dutta

Abstract


Colorectal carcinoma has etiopathogenesis related to both environmental and genetic factors. Epidermal growth factor receptor (EGFR) and its downstream signaling pathways regulate the key cellular events that drive the progression of many neoplasms. Thirty cases of colorectal carcinoma (CRC) were studied using H&E stain for morphology, grade and stage and further IHC was done for EGFR mutations. Our study found that the poorly differentiated adenocarcinoma and moderately differentiated adenocarcinoma showed stronger EGFR staining as compared to well differentiated adenocarcinoma. So, higher the grade of tumor, stronger is the EGFR positivity. EGFR expression detection by IHC is a sensitive and specific marker in CRC. The findings of positivity will help in guiding the therapy and better survival in patients of CRC.


Keywords


EGFR (Epidermal Growth factor Receptor), IHC (Immunohistochemistry), H&E (Hematoxylin and Eosin stain), CRC (Colorectal carcinoma)

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