A STUDY OF EXPRESSION OF THYROID TRANSCRIPTION FACTOR (TTF-1) IN ENDOMETRIAL ADENOCARCINOMA OF UTERINE CORPUS

Dr .M. Brinda, Dr. S. Maheswari, Dr. Sasikumar Sambasivam

Abstract


Among females endometrial carcinoma is  the  most frequent  malignancyworldwide. Thyroid transcription factor has been regarded as a specific and sensitive marker for  tumors arising  in thyroid and lung. But some studies   state that TTF 1 marker is also expressed in endometrial adenocarcinoma. The aim of this study is to  probe  the incidence  of  Thyroid transcription factor expression  in primary uterine endometrial adenocarcinoma  and to correlate the percentage of expression of TTF-1 with the grade of endometrial adenocarcinoma. TTF 1 immunohistochemistry was done for 50 cases out of which two cases of  moderately differentiated  endometrioid  adenocarcinomas and 1 case of  poorly differentiated endometrioid adenocarcinoma  showed focal and diffuse positivity respectively .


Keywords


Endometrial carcinoma, TTF 1

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