COMPARISON OF INCIDENCE OF CONGENITAL- ANOMALIES IN DIFFERENT IVF-PROCEDURES

Dr Monica Singh, Dr Randhir Singh

Abstract


Background:  A retrospective cohort study was conducted to evaluate and compare the incidence  of congenital anomalies in babies and fetuses conceived after four procedures of assisted reproduction techniques (ART)- IVF, ICSI, IVF-FET and ICSI-FET.

Material and Methods The prevalence of congenital anomalies was compared retrospectively between ALL ART  babies and fetuses conceived via all procedures of  IVF-ICSI (ART) - in vitro fertilization with standard insemination (IVF), IVF with Intracytoplasmic sperm injection (ICSI), IVF with frozen embryo transfer (FET- IVF), and ICSI with frozen embryo transfer (FET-ICSI). Congenital anomalies were described according to European Surveillance of Congenital Anomalies (EUROCAT) classification. The parental backgrounds, biologic parameters, obstetric parameters, and perinatal outcomes were compared between babies and fetuses with and without congenital anomalies. Data were analyzed by the generalized estimating equation.

 Results: All IVF-ICSI-FET (ART)  evolutionary pregnancies were included in the analysis. Our present study showed 04%  babies and fetuses had a congenital anomaly . The major incidence found among the recorded anomalies were congenital heart defects, chromosomal anomalies, and urinary defects. However, the risk of congenital anomalies in babies and fetuses conceived after FET was not increased compared with babies and fetuses conceived after fresh embryo transfer, even when adjusted for confounding factors.

Conclusion: There is no increased risk of congenital anomalies in babies and fetuses conceived by fresh versus frozen embryo transfer after in vitro fertilization with and without micromanipulation. Indeed, distribution of congenital anomalies found in our study population is consistent with the high prevalence of congenital heart defects, chromosomal anomalies, and urinary defects that have been found by other authorsalso  in children conceived by infertile couples when compared to children conceived spontaneously

Keywords


Congenital Anomalies . In Vitro Fertilization (Ivf) . Intra Cytoplasmic Sperm Injection (Icsi). Frozen Embryo Transfer(Fet). Perinatal Outcomes

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