TO STUDY THE EFFECT OF GLUCOSE-INSULINPOTASSIUM TREATMENT IN ACUTE MYOCARDIAL INFARCTION PATIENTS

Reena Gandhi, Suman Rana, Harender Simar

Abstract


Acute myocardial infarction(AMI) is a one of the commonest diagnosis in patient reporting in emergency department with high mortality rate if delay in early treatment initiation. The pathophysiological mechanism of AMI is the rupture of an artherosclerotic plaque in an epicardial coronary artery, exposing sub endotheial tissue to a subsequent thrombogenic response and leading to a complete obstruction of the vessel. Strategies directed towards achieving early and sustained re-perfusion of the infarct related artery have reduced mortality. Thrombolytic agents, aspirin, anti-platelet agent, beta- blockers & ACE inhibitors have been used as routine treatment during the early hours of AMI. Glucose- Insulin- Potassium have multiple metabolic effects which changes the metabolic / physiological function in infarction patients. According to inclusion & exclusion criteria, 50 patients were enrolled in the study. Patients were randomly divided into two equal groups, control group received routine usual treatment and GIK group received Glucose- Insulin- Potassium infusion. Various parameters like blood glucose level, serum electrolyte, ECG, Heart rate, Blood pressure, fluid input and output etc. were monitored at pre determined time interval and recorded for analysis. Glucose-Insulin-Potassium (GIK) infusion in acute myocardial infarction patients reduces the mortality rate as compared to the usual care. In comparison to the usual care the GIK infusion has less incidence of cardiogenic shock and heart failure.


Keywords


acute myocardial infarction (AMI), Glucose- Insulin- Potassium infusion (GIK), Cardiogenic shock,

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