STUDY BIOCHEMICAL PARAMETER TOTAL PROTEIN AND ALBUMIN IN OVARIAN TUMORS BEFORE AND AFTER CHEMOTHERAPY

Dr. Goda Veena Murty, Dr. O Anjaneyulu, Dr. M. L. Rajeswari

Abstract


Malignant disease has been shown to be associated with low albumin. Albumin has been shown to be a prognostic marker in colorectal cancer, glioblastoma multiforme, gastric cancer and breast cancer.Ovarian cancer patients are more likely to present with poor nutritional status and cachexia. They are  more likely to experience rapid changes in their nutritional status and body composition. Studies showed that ovarian cancer patients are more likely to have low serum protein levels and malnutrition. The current study is designed with an aim to explore the changes in Total Protein and Albumin of malignant and benign ovarian tumors pre therapy and post therapy.

The mean age of the patients were found to be 44.77 ± 11.66. Mean age of the patients with malignant tumors (n=29) was 47.7 to ± 9.26 years whereas for benign tumors (n=11) it was only 37± 4.34 years. The pre treatment protein levels in patients with benign tumours were 11.05±6.31 g/dl and post treatment levels were found to be 7.90±3.60 g/dl.  (p=0.08) 

In malignant tumours pre treatment mean levels of proteins was10.38 ± 7.67 g/dl and post treatment level was 7.03 ±0.4.02 g/dl(p =0.001) while the reduction in albumin level post therapy was statistically significant(p<0.0001). A positive correlation was found between CA125 levels and total protein, albumin. The total protein and albumin levels showed a significant reduction in malignant tumors whereas it was not significant in benign tumors

 


Full Text:

PDF

Refbacks

  • There are currently no refbacks.