SIGNIFICANCE OF TUMOUR MARKERS(CEA AND CA15-3) IN CARCINOMA BREAST

Dr. Ashok Kshirsagar, Dr. Nehadeepkaur Chadha

Abstract


INTRODUCTION: Breast cancer is a major public health problem for Women throughout the world. In the United States,
breast cancer remains the most frequent cancer in women and the second most frequent cause of cancer death.
Objective:To study the significance of Tumour Markers (CEA and CA15-3) in carcinoma breast.
MATERIAL AND METHODS: This study was conducted in KRISHNA HOSPITAL and MEDICAL RESEARCH CENTRE,
KARAD during the period from June 2017 to June 2019. The study comprises of a total of 50 cases that were admitted in this
hospital. On admission case history was noted and the patients were examined clinically. In this study the TNM staging
system was followed and blood samples were collected in plain bulbs. The study was approved by Institutional Ethical
Committee. Informed consent was obtained from each patient prior to sample collection.
RESULTS AND CONCLUSIONS: In 13/24 cases with abnormal CA15-3 value in postoperative follow up period, there
are 54% patients with metastatic disease.In 4/24 cases with preoperative abnormal CA15-3, metastasis occurred in 75%
and loco-regional recurrence occurred in 50%.In 8/50 cases with preoperative abnormal CA15-3, 75% patients
presented with locally advanced disease.In 9/24 cases with abnormal CEA value in postoperative follow up period,
there are 67% patients with metastatic disease.In 15/24 cases with preoperative abnormal CEA, metastasis occurred in
40% and in 16/24 cases with preoperative abnormal CEA, loco-regional recurrence occurred in 25%.In 32/50 cases with
preoperative abnormal CEA, 63% patients are presented with locally advance disease.


Keywords


CEA, CA15-3, TNM staging, Tamoxifen

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