POSTPARTUM PROPHYLAXIS WITH SHORTCOURSE MAGNESIUM SULPHATE REGIME IN WOMEN WITH SEVERE PREECLAMPSIA

Dr. P. Amudha, Dr. Dhivya. R

Abstract


OBJECTIVE: To compare the effectiveness of 12 hours short course postpartum magnesium sulphate therapy versus 24 hours
standard regime in stable patients with severe preeclampsia.
METHODS: This randomized controlled trial on 100 women with severe preeclampsia was conducted in a tertiary hospital,
between 2017-2018. Fifty women received postpartum MgSO4 for 12 hours and 50 for 24 hours. Groups were compared for
occurrence of eclamptic fit, side effects , toxicity profile, & feto maternal outcome.
RESULTS: The two groups did not have any significant difference in gestational age, gravidity, BMI, blood pressure, proteinuria,
antihypertensive use , side effects, ICU admission, and toxicity profile. Two women from either group developed convulsions and
MgSO4 was reinstituted for 24hours. Diuresis in 12 hour group was statistically significant. Increased NICU admission and
perinatal deaths in both groups were due to prematurity.
CONCLUSION: Short course postpartum MgSO4 therapy in stable women with severe preeclampsia was equally effective as
the 24 hours therapy with similar feto-maternal outcomes and added benefits of reduced total drug dose and side effects.


Keywords


Magnesium Sulphate, Severe Preeclampsia , Shortcourse.

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