A STUDY OF HIV-TB COINFECTION USING CBNAAT IN A RURAL MEDICAL COLLEGE HOSPITAL

Dr.C.Manjula Vani Kiran, Dr. A. Smita Reddy

Abstract


Tuberculosis remains the most common opportunistic infection among HIV positive individuals.  HIV-TB co-infected individuals are at high-risk of death. This study was conducted  to find the prevalence of HIV –TB coinfection and trends at Government General Hospital, Government Medical College, Suryapet by using cartridge based nucleic acid amplification test [CBNAAT] as a diagnostic tool and to determine Rifampicin resistance among patients with HIV-TB co-infection. A total of 500 HIV patients were in the study. Out of these patients 71 MTB (14.2%)  cases were detected. Of these 71 cases 68 (95.8%) cases were sensitive to Rifampicin (RIF) and 3 (4.2%) cases were showing resistance to Rifampicin (RIF) drug.  Co-existence of HIV and tuberculosis is high and there is high prevalence of MDR tuberculosis in HIV patients. CBNAAT/RIF can be used as initial test in detecting Tuberculosis in PLHIV, because of its rapidity and detection of Rifampicin resistance


Keywords


Co-infection, Human immune deficiency virus(HIV), Catridge based nucleic acid amplification testing, Rifampicin , Tuberculosis

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