ASSOCIATION BETWEEN KIDNEY DISEASE AND PRE-DIABETES BY PLASMA GLUCOSE AND HBA1C LEVELS ON NORTH BIHAR

Dr.Pankaj Mohan Shrivastava, Dr.(Prof.) K. K. Singh

Abstract


Introduction: Chronic kidney disease is recognized as a global health problem. Growing evidence links prediabetes toalbuminuria and CKD and this association is a matter of concern worldwide nowadays.The study aims to find the association between kidney disease and prediabetes and compare it with normoglycemic controls.

Purpose: To study the association between Kidney disease and Prediabetes.

Material And Methods: It is a case control study (100 Prediabetic cases and 50 normoglycemic controls).Both prediabetic menand women >20 years were taken with FBS>100mg/dl but<126mg/dl and/or PPBS>140 mg/dl but<199mg/dl and/or HbA1C 5.7-6.4%as per American Diabetes Association Criteria. CKD was defined by eGFR- 15- 59 per 1.73m2 and/or albumin creatinine ratio 30-300mg/g(microlbuminuria) and>300 mg/g(macroalbuminuria).

Result: Of the total 100 cases and 50 contols 9% cases and none of the controls showed microalbominuria. 7% cases andnone of the controls showed macroalbuminuria (Chi square-8.96, p value- 0.005). 16% cases and none of the controls were under stage 3 and 4 of CKD.(Chi square-9.65, p value-0.05).Overall 18% prediabetic cases and no normoglycemic controls showed evidence of kidney disease.

Conclusion: Kidney disease prevalence is high among people with prediabetes.Prediabetes can be a target for early interventionby lifestyle changes and control of modifiable risk factors for preventing and/or progression of CKD in these individuals.


Keywords


Albumin creatinine ratio, Albuminuria, Chronic Kidney Disease, Macroalbuminuria, Microalbuminuria,Prediabetes

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