EFFECT ON TOTAL LEUCOCYTE COUNT AND SIGNIFICANCE OF TOTAL LEUCOCYTE AND PLATELETS WITH SEROSITIS IN ADULTS IN EARLY FEBRILE PERIOD OF NS1 ANTIGEN POSITIVE PATIENTS

Dr Rajpal Verma, Dr Nidhi Anand, Sunil Kumar Chamola, Dr (Capt) Shikha Verma, Dr Shivam Singla

Abstract


OBJECTIVES: To study the effect on total leucocyte count and their significance as well as of platelet count with serositis  in patients of short duration febrile illness with NS1 antigen positivity.INTRODUCTION:NS1 ANTIGEN was used to diagnose dengue infection and various flavivirus infections. Leucopenia , a well described feature is caused by bone marrow suppression by dengue virus. Selective leakageof plasma in pleural and peritoneal cavity due to functional change in vascular integrity .  MATERIAL AND METHODS: An observational study done retrospectively  .  Cases of febrile illness who tested positive for NS1 ANTIGEN (RDT) from the period of july 2018 to November 2018 were studied for presence of leucopenia , thrombocytopenia and serositis. RESULT: leucopenia is a common finding in NS1 positive patients. However , there was no association seen of leucopenia or thrombocytopenia with presence of serositis 

Keywords


NS1 Antigen , leucopenia ,serositis, thrombocytopenia

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