SERUM LEVEL OF LEPTIN AND GHRELIN AS SUCCESS MARKER OF LAPAROSCOPIC SLEEVE GASTRECTOMY- A PROSPECTIVE COHORT STUDY

Shailesh kumar, Shazid Akbal, Tayod Kumar Choudhary

Abstract


Introduction- Leptin  binds to its receptors influences the activity of various hypothalamic neurons and the expression of various orexigenic and anorexigenic neuropeptides. Ghrelin being an orexigenic hormone plays an important role in initiating food intake and ending meal.

Material and methods- The prospective observational study  were performed after Laparoscopic Sleeve  Gastrectomy (LSG) for obesity as per the recommendation of WHO guideline. Post-operatively all patients were assessed with serum level of Leptin and Ghrelin level and their relation with their weight and BMI.

Discussion- On Univariate analysis, Only BMI was significantly affecting Leptin expression with beta coefficient of .431 (p= .004). Univariable regression analysis for Ghrelin showed no correlation with age, weight  and BMI   

Conclusion- LSG is an effective procedure for obesity showed decrease in serum level of Leptin and Ghrelin on subsequent follow-ups. Only BMI was found to have significant correlation with the Leptin expression

 


Keywords


- LSG, Leptin , Ghrelin

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