ANTIMICROBIAL RESISTANCE PROFILE OF ACINETOBACTER BAUMANNII IN A TERTIARY CARE CENTRE.

Dr Gurpreet Singh Bhalla, Dr Dinesh Kumar Kalra, Dr Sanjay Pratap Singh, Dr Rakhi Negi

Abstract


Acinetobacter baumannii is one of the significant pathogens to cause healthcare-associated infection worldwide, mainly infecting critically ill patients. The present study aimed to analyse the antimicrobial resistance of Acinetobacter baumannii in a tertiary care hospital. Acinetobacter baumannii isolates were identified during one year period in a tertiary care hospital. Antimicrobial susceptibilities were determined for 238 isolates by Kirby-Bauer disk diffusion method and VITEK2-AST cards (Biomérieux, France) according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Majority of samples analysed were from inpatient (91.6%) and predominantly from tracheal aspirates. The isolates of Acinetobacter baumannii were most resistant to piperacillin (97.61%), ceftazidime (95.71%) and least resistant to colistin (3.26%). The drug of choice in multidrug-resistant strains of Acinetobacter spp. are carbapenems and 83.62% isolates of Acinetobacter baumannii were resistant to imipenem. There is a high incidence of resistant isolates of Acinetobacter baumannii to a majority of antimicrobial classes, including carbapenems. This study will guide the empirical therapy and suggest that surveillance of antimicrobial resistance of Acinetobacter baumannii is necessary.


Keywords


Acinetobacter baumannii, antimicrobial resistance

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