LUNG CANCER AND SMOKING

Dr. Venus Sharma, Dr. Manmeet pal kaur

Abstract


One of the leading cause of cancer related deaths worldwide is Lung Cancer. Over 1 million people  die due to Lung cancer each year worldwide. Almost 90% of Lung cancer in men & 70 %-80% in women is explained by cigarette smoking. Non small cell lung cancer (NSCLC) represents the most frequently diagnosed subtype of this morbid malignancy. Various  genetic & epigenetic abnormalities contributes to clinically evident lung cancers. These abnormalities lead to activation of oncogenes and inactivation of tumor suppressor genes .Both smoking and genetic abnormality leads to chronic inflammation, which promotes cancer. These mediators in turn may be responsible for increased macrophage recruitment, delayed neutrophil clearance, and increase in reactive oxygen species (ROS). Thus, the pulmonary environment presents a unique milieu in which lung carcinogenesis proceeds in complicity with the host cellular network.


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