Sunil Saini



This study investigates the therapeutic potential of oral curcumin with piperine in the palliative management of advanced squamous cell carcinoma of head and neck region.


40 patients with advanced, incurable or metastatic squamous cell carcinoma of head and neck region or those who have failed all standard treatment were included in this study without randomization. Patients received capsules of curcumin with piperine (3.6 g/day) for a period of 8 weeks.QOL was assessed using EORTC QLQ-C30 (version 3) & QLQ-H&N35 questionnaires.


A significant improvement in global health status, pain, fatigue, constipation and financial difficulty scores was observed at the end of treatment. The study therapy was well tolerated and no grade 3/4 toxicities were observed.


The present study indicates the therapeutic potential of curcumin and piperine in the palliative treatment of advance head and neck cancer as a cost-effective substitute.



Head and neck sq cell cancer (HNSCC), curcumin, quality of life (QOL)

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