Kamlesh Taori, Seema Seth


Introduction/ Background: In hypothyroidism, hypertension is not a usual sign but hypothyroidism is one of major
however often ignored cause of hypertension, which can be easily treated with thyroxine therapy most of the times. This
study was undertaken to find the relationship of thyroid function with blood pressure and compare the age-related increase in blood pressure in
euthyroid patients with that of hypothyroid patients and to assess the effect of thyroid hormone replacement therapy on blood pressure in
hypertensive hypothyroid patients.
Objective: To study the association between hypertension and hypothyroidism and to assess the response of adequate thyroid hormone
replacement therapy on blood pressure in hypothyroid hypertensive subjects.
Material and Method: Prospective observational study was undertaken in Rohilkhand Medical College and Hospital, Bareilly. This study
included 241 female patients aged 19-69years admitted in the medical wards from 1st Jan to 31st Dec 2018. Detailed clinical examination
including measurement of blood pressure and routine investigations including thyroid profile were done. The data was expressed as means ±
SEM and was statistically analyzed.
Results: On the basis of thyroid profile out of 241 cases, 87 were hypothyroid and 154 were euthyroid. Adiposity, age and sex related factor that
could influence blood pressure were excluded. Diastolic, rather than systolic blood pressure was significantly higher in hypothyroid patients
over 50 years than in euthyroid patients of corresponding age groups. 9 hypertensive hypothyroid patients who received adequate thyroid
replacement therapy for 6 ± 2 months had reduction in blood pressure . In rest of 5 patients who did not receive adequate thyroid replacement
therapy due to poor compliance, blood pressure and thyroid function tests remained unchanged.
Conclusion: In patients over 50years , we encountered hypertension more in hypothyroid patients than in euthyroid cases. Hypothyroid
patients had significantly higher diastolic blood pressure than euthyroid patients . Hypertension that was associated with hypothyroidism often
reduces in response to adequate thyroid hormone replacement therapy

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Asvolt B O, Bjorn T, Nilsen T and Vatten L J The Journal of Clinical Endocrinology & Metabolism, Volume 92, Issue 3, 1 March 2007, Pages 841–845


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