EPIDEMIOLOGY, CLINICAL AND HISTOPATHOLOGICAL PROFILE OF PATIENTS WITH PRIMARY LOCALIZED CUTANEOUS AMYLOIDOSIS (PLCA) IN A TERTIARY CARE HOSPITAL IN MUMBAI

Dr Swagata Arvind Tambe, Dr Hemangi Jerajani

Abstract


Background: Primary localized cutaneous amyloidosis (PLCA) is one of the common pigmentary disorders in
dermatology.
Aims: To study epidemiological and clinical profile of patients with PLCA. To study utility of H & E stain, Thioflavin-T stain & direct
immunofluorescence (DIF) for demonstration of amyloid deposits.
Methods: Patients of both sexes, aged 18 to 65 years were included. Detailed history & clinical examination was followed by skin biopsy for H&
E stain, Thioflavin-T stain and DIF studies.
Results: Sixty-five patients with clinical diagnosis of PLCA were studied. Mean age of presentation was 38.76 years with female preponderance.
Macular amyloidosis (84.61%) was the commonest type followed by lichen amyloidosis (50%). Amyloid was demonstrated by H&E stain in
63.07 % of the cases, by Thioflavin-T stain in 64.61 % of the cases and by DIF in 44.61 % of the cases.
Conclusions: H& E stain was found to be equally effective for diagnosis of PLCA compared to special stains.


Keywords


Macular. lichen amyloidosis, Thioflavin T stain, DIF

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