HISTOPATHOLOGICAL OBSERVATIONS FROM RENAL BIOPSY: A SINGLE CENTRE EXPERIENCE FROM MAHARASHTRA, INDIA

Dr. Geeta Sheth, Dr. Yogesh Sadashiv Thube, Dr. Shweta Manoharrao Watane, Dr. Shilpa Domkundwar, Dr. Narendra M Dedhia

Abstract


Introduction: Incidence of glomerular disease varies worldwide depending upon age, gender, and geographical region. Understanding the aetiology is very important for management of these diseases. Biopsy based technique helps in precise diagnosis and improved treatment outcomes.

Aim: This study aimed to classify glomerular diseases based on histopathological findings of renal biopsies in patients below 20 years to above 60 years.

Materials and Methods: This cross-sectional study was conducted at Department of Nephrology, Grant Medical College and Sir JJ Group of Hospitals, Mumbai between October 2017 and August 2019 among patients who underwent renal biopsy. Histological diagnosis was performed using light microscopy, electron microscopy and immunohistochemistry staining. Histological findings were divided into primary glomeruli disease (PGD), secondary glomeruli disease (SGD), tubulointerstitial disease (TID) and others. Statistical analysis was done using one sample t-test to determine the differences in disease frequencies.

Results: Total of 189 patients (102 men and 87 women) included were from age of 3‑90 years. The mean (SD) age was 31.11 (16.05) years. The most common histological disease was PGD (48.67%) followed by SGD (33.33%) and TID (6.34%). Incidence of SGD was more common in elderly patients (>60 years). Among total population, incidence of focal segmental glomerulosclerosis (FSGS) (14.81%) and lupus nephritis (LN) (11.11%) were highest in PGD and SGD observed, respectively. Incidence of diabetic nephropathy (DN) was highest (33.33%) in elderly population (>60 years). In PGD, incidence of membranous glomerulonephritis (MGN) was significantly higher in men (87.5%) compared to women (12.5%) (p=0.001); however, in SGD, incidence of LN was significantly common in women (85.71%) compared to men (14.29%) (p=0.015).

Conclusion: FSGS and LN were prevalent PGD and SGD, respectively. Incidence of MGN was most common in men while, LN was prevalent in women who underwent renal biopsy.


Keywords


Diabetic nephropathy, elderly population, focal segmental glomerulosclerosis, lupus nephritis

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References


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