EVALUATION OF MICROALBUMINURIA IN TYPE II DIABETIC MELLITIS PATIENTS BY AUTOMATED URINE ANALYSIS

Vennela D, Madhukar Reddy Kadaru

Abstract


AIMS AND OBJECTIVES

The prevalence of Diabetes Mellitus is growing rapidly worldwide and iNephropathy is an important complication which is the leading cause of End Stage Renal Disease. The earliest manifestation of Diabetic Nephropathy being microalbuminuria can be present in NIDDM patients at the time of diagnosis.But prompt recognition helps in intervention.This study is to document and analyse the findings of automated complete urinogram among proven type 2 diabetes mellitus patients while studying the levels of albuminuria and correlate cases of microalbuminuria with age, sex, duration since diagnosis of diabetes.

MATERIALS AND METHODS:

Data for the current study was collected from outpatients attending the attached hospitals of GMC&GH, Suryapet during the period from JULY 2018 to June 2019.  Based on levels of albuminuria the patients were categorized into normoalbuminuria with <30 mg/gm of creatinine, microalbuminuria with 30- 300mg/gm of creatinine, and macroalbuminuria with >300mg/gm of creatinine. Hypertension, Ischemic heart disease,myocardial infarction, Diabetic neuropathy defined by signs and symptoms of neuropathy and Diabetic retinopathy defined by signs of retinopathy on slit lamp biomicroscopy. Detail history, examination followed by investigations-Fasting Blood Sugar, Postprandial Blood Sugar, Glycosylated Haemoglobin, Lipid Profile, Urine analysis by dipsticks, estimation of albumin creatinine ratio and urine microscopy wasdone.

RESULTS: In the present study it was noted that among 500 patients studied, microalbuminuria was common in males, prevalence of microalbuminuria was 20% and correlated with duration. Most of the cases were accumulated in the first five years since diagnosis of diabetes, showing positive correlation with HbA1c values more than 7%, serum total cholesterol >200 mg/dl, serum triglycerides >150 mg/dl, HDL < 35 mg/dl and withhypertension.

Conclusion:

Testing for microalbuminuria should be standardized in type 2 diabetes mellitus patients from time of first diagnosis of diabetes because early intervention helps in delaying the progression of diabetic nephropathy. Microalbuminuria independently is significantly associated with male gender, cardiovascular risk factors like hypertension and dyslipidemia.


Keywords


Albuminuria, Body Mass Index, Dyslipidemia.

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References


Anirban Maitra. The endocrine system. In : Robbins and Cotran, editor, Text book of Pathologic basis of disease. 8th edition, New York : Elsevier; 2010. p.131.

BB Tripathy. Landmarks in the history of diabetes. In: BB Tripathy, editor, RSSDI Text book of diabetes mellitus. Chapter-2, 2nd edition, Vol.1, New Delhi : Jaypee Publications; 2008.p.6

BB Tripathy. Landmarks in the history of diabetes. In: BB Tripathy, editor, RSSDI Text book of diabetes mellitus. Chapter-2, 2nd edition, Vol.1, New Delhi : Jaypee Publications; 2008.p.7

Papaspyros NS. The history of diabetes mellitus. 2nd edition, Georg Thieme Verlag Stuttgert;1964.

BB Tripathy. Landmarks in the history of diabetes. In: BB Tripathy, editor, RSSDI Text book of diabetes mellitus. Chapter-2, 2nd edition, Vol.1, New Delhi : Jaypee Publications; 2008.p.8

Leonid Poretsky. Principles of diabetes mellitus 2nd edition. New York: Spriger; 2009.p3.

Cahill GF Jr. Current concepts of diabetes. In : Marble A, Krall LP, Bradely RF, et al (Eds): Joslins Diabetes Mellitus. 12th edition, Philadelphia: Lea and Febiger;1985.

AnjanaRM,AliMK,PradeepaR,DeepaM,DattaM,UnnikrishnanR,etal.

The need for obtaining accurate nationwide estimates of diabetes prevalence in India Rationale for a national study on diabetes. Indian J Med Res 2011;133:369-380.

Modi GK, Jha V. The incidence of ends Stage renal disease in India-A population based study. Kidney International2006;2131-2133.

Nephropathy in Diabetes- Diabetes care; 2004; 27(1):s79-s83.

European Urinalysis Guidelines. Scand J Clin Lab Invest2000;60:18.

Muhammad Yakoob Ahmedani, Muhammad Zafar Iqbal Hydrie, Azhar Iqbal, AsmaGul,WaheedBaigMizra.Prevalenceofmicroalbuminuriaintype2

diabetic patients in Karachi : Pakistan A multi-center Study. Journal of Pakistan Medical Association 2005;55:382.


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